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Scanned 6 citations against PubMed, CrossRef, and Retraction Watch:
π₯ Critical: Citation #5 is RETRACTED β Raoult et al. (Int J Antimicrob Agents, 2020) was retracted Dec 2024 after a 4-year investigation. Ethics violations and methodology flaws confirmed. This must be removed.
π₯ Critical: Citation #8 is RETRACTED β LesnΓ© et al. (Nature, 2006) was retracted June 2024 for image manipulation including splicing, duplication, and eraser tool use on key figures. The foundational AΞ²*56 Alzheimer's hypothesis paper β must be removed.
| Citation | Journal | Year | Status | Issue |
|---|---|---|---|---|
| #4 β Marso SP (SUSTAIN-6) | NEJM | 2016 | Active | β |
| #5 β Raoult D et al. | Int J Antimicrob Agents | 2020 | β RETRACTED | β Ethics + methodology |
| #6 β Zinman B (EMPA-REG) | NEJM | 2015 | Active | β |
| #7 β Lincoff AM (SELECT) | NEJM | 2023 | Active | β |
| #8 β LesnΓ© S et al. | Nature | 2006 | β RETRACTED | β Image manipulation |
| #9 β Estruch R (PREDIMED) | NEJM | 2013 | β RETRACTED & REPUBLISHED | β Randomization errors |
Only 50% of citations are clean. #5 and #8 must be removed. #9 was retracted in 2018 but republished with corrected analysis β cite the 2018 republished version (DOI: 10.1056/NEJMoa1800389).
Three well-designed RCTs that properly evaluated HCQ for COVID-19:
| Paper | Year | Design | N | Evidence |
|---|---|---|---|---|
| Boulware DR et al., NEJM | 2020 | Double-blind RCT | 821 | Level 1b |
| RECOVERY Collaborative, NEJM | 2020 | Open-label RCT | 4,716 | Level 1a |
| Cavalcanti AB et al., NEJM | 2020 | Open-label RCT | 667 | Level 1b |
All three found no clinical benefit of hydroxychloroquine. The RECOVERY trial (n=4,716) is the largest and most definitive.
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What researchers say
βBuilding with LancetClaw, we have a whole new standard for evidence quality in our research group. It caught three retracted papers in our latest systematic review.β
Dr. Sarah Chen
Associate Professor, Stanford Medicine
Prof. James Wright
Editor-in-Chief, BMJ Evidence-Based Medicine
βWe integrated LancetClaw into our peer review workflow. The citation verification is incredibly fast and accurate.β
Dr. Maria Santos
Research Director, Karolinska Institute
βLancetClaw caught a retracted paper in our systematic review that we would have missed entirely. It saved months of work.β
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